Anesthesiology 2017 Oct; 127(4):695-708
Hydrogen Peroxide Induces Muscle Nociception via Transient Receptor Potential Ankyrin 1 Receptors.
Sugiyama D, Kang S, Arpey N, Arunakul P, Usachev YM, Brennan TJ
H2O2 has a variety of actions in skin wounds but has been rarely studied in deep muscle tissue. Based on response to the transient receptor potential ankyrin 1 antagonists after plantar incision, we hypothesized that H2O2 exerts nociceptive effects via the transient receptor potential ankyrin 1 in muscle.