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Shafer SL, Dexter F: Publication bias, retrospective bias, and reproducibility of significant results in observational studies. Anesth Analg; 114(5):931-2 Kang S, Jang JH, Price MP, Gautam M, Benson CJ, Gong H, Welsh MJ, Brennan TJ: Simultaneous Disruption of Mouse ASIC1a, ASIC2 and ASIC3 Genes Enhances Cutaneous Mechanosensitivity. PLoS One; 7(4):e35225 Kumar AB, Schweiger HW: Intraoperative use of a chest physiotherapy system during whole lung lavage for pulmonary alveolar proteinosis. Ther Adv Respir Dis Dexter F: Iowa satisfaction with anesthesia scale. Korean J Anesthesiol; 62(3):297 Loftus RW, Brown JR, Koff MD, Reddy S, Heard SO, Patel HM, Fernandez PG, Beach ML, Corwin HL, Jensen JT, Kispert D, Huysman B, Dodds TM, Ruoff KL, Yeager MP: Multiple Reservoirs Contribute to Intraoperative Bacterial Transmission. Anesth Analg Ueda K, Ross AF, Ahmed W: In reply. Anesthesiology; 116(4):968-9
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The Department of Anesthesia at the University of Iowa is a leader in clinical and basic science research. Clinical investigations occur in all subspecialties including critical care and cardiothoracic, neurosurgical, and regional anesthesia. Basic science research topics are pain, analgesic pharmacology and learning and memory. There is an emphasis on training physicians and scientists on the fundamentals of basic and clinical research. The Department of Anesthesia is keenly interested in providing residents and fellows with the background for developing a career in research.
Surgical Intensive Care Unit Research
Operations Research (Management Consulting)
Pain Research
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| Grants Recently Awarded and Submitted |
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Grants Recently Awarded
| 07/2011 |
NIH, Christina Spofford, PI, “Voltage Gated Sodium Channels in Acute Post Laminectomy Pain.” |
| 05/2011 |
NIH, Timothy Brennan, Co-I, “Regulation of TRPV1 and Nociceptor Sensitization by the Complement System.” |
| 04/2011 |
Program Project Grant, James Bates, Co-I, “Cellular S-nitrosothiol Signaling in Respiratory Biology” |
| 04/2011 |
NIH, Bradley Hindman, Co-I, Michael Todd, Co-I, “Intubation Mechanics of the Stable and Unstable Cervical Spine.” |
| 04/2011 |
Array BioPharma, Inc., Timothy Brennan, PI, “Array/Cubist Drug Trial for Postoperative Pain.” |
| 03/2011 |
Galleon Pharmaceuticals, Timothy Brennan, PI, “Galleon Trials for Rat Incision Models of Post-operative Pain.” |
| 02/2011 |
Department of Defense, Blanca Marquez de Prado, PI, “Role of Nerve Growth Factor in the Inflammatory Response and Pain in a Mouse Neurofibromatosis Model.” |
| 02/2011 |
NIH, Donna Hammond, Co-I, “Chemokines, TRP Channels and Cancer Pain.” |
| 01/2011 |
Ironwood Pharmaceuticals, Timothy Brennan, PI, Evaluation of Ironwood Compound in the Incisional Model of Post-surgical Pain.” |
| 11/2010 |
Grow Iowa Values Fund, Max Baker, PI, “Optimization of Novel Anticonvulsant Alkyl-(1-hydroxy-2,2,2-trifluoroethyl) Phenolic Compounds” |
| 09/2010 |
NIH, Robert Block, Co-I, “Marijuana Use and Schizophrenia.” |
| 09/2010 |
NIH, Joss Thomas, Co-I, “Effects of General vs. Regional Anesthesia in Infant Neurodevelopment and Apnea.” |
| 09/2010 |
NIH, Robert Block, Co-I, “Brain Development in Adolescents with Genetic Risk Factors for Alcoholism.” |
| 08/2010 |
Adynxx, Inc., Timothy Brennan, PI, “Adynxx Trial: Testing the Reproduction of AYX1 Analgesic Effect in the Rat Incision Model of Post-Operative Pain.” |
| 07/2010 |
NIH, Marlene Cano, PI, “Persistent Pain and Opioid Mechanisms in the Rostroventral Medulla.” |
Grants Recently Submitted
| 07/2011 |
NSF, Toshi Kitamoto, PI, "Modulation of Adult Behavior by Brain-derived Ecdysteroids through a G-protein Coupled Ecdysteroid Receptor in Drosophila" |
| 06/2011 |
NIH, Toshi Kitamoto, Co-I, “Genetic Analysis of Nociceptor Sensitization” |
| 05/2011 |
International Association for the Study of Pain, Donna Hammond, Co-I, “Signal Switching in the Rostroventral Medial Medulla: Revision of Conventional Hypotheses of Opioid-Mediated Analgesia” |
| 05/2011 |
Anesthesia Patient Safety Foundation, Max Baker, PI, “Identification of Sevoflurane Reactive Intermediates as Potential Mediators of Cognitive Deficits and Hepatic Dysfunction” |
| 04/2011 |
FDA, Joss Thomas, Co-I, “The GAS Trial-Neurocognitive Outcome of Regional vs General Anesthesia in Infants” |
| 02/2011 |
International Association for the Study of Pain, Christina Spofford, PI, “A New Model of Postoperative Pain in Rats” |
| 02/2011 |
International Anesthesia Research Society, Kenichi Ueda, PI, “A Comparison of Three Arterial Cannulation Techniques: Ultrasound-Image, Doppler-Guided,Versus Palpation” |
| 01/2011 |
NIH, Robert Block, PI, “General Anesthesia during Human Infancy and Brain Development” |
| 01/2011 |
American Pain Society, Christina Spofford, PI, “Neurotrophin Expression and Excitability of Rat DRG Neurons after Laminectomy” |
| 01/2011 |
NIH, Donna Hammond, Co-I, “Inflammation-induced Plasticity of Nicotinic Receptor Mediated Antinociception” |
| 01/2011 |
American Federation for Aging Research, Christina Spofford, PI, “Acute Post Laminectomy Pain in Aging” |
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| Investigator Spotlight: Max T. Baker, Ph.D. |
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 I received my doctorate in pharmacology at the University of Georgia College of Pharmacy studying the effects of dietary fats on carcinogen metabolic activation. After a postdoctoral fellowship at the Mayo Clinic, where I studied the metabolism of anesthetics and halogenated compounds by the cytochrome P450 enzyme system, I came to The University of Iowa in 1984. At the time, there was interest in the metabolism and toxicity of small fluorinated compounds as they were employed not only as anesthetics but as the new non-chlorinated refrigerant substitutes. Read more...
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