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Spofford CM, Ashmawi H, Subieta A, Buevich F, Moses A, Baker M, Brennan TJ: Ketoprofen Produces Modality-Specific Inhibition of Pain Behaviors in Rats After Plantar Incision. Anesth Analg; 109(6):1992-1999 Bellinger A, Siriwetchadarak R, Rosenquist R, Greenlee JD: Prevention of Intrathecal Baclofen Withdrawal Syndrome: Successful Use of a Temporary Intrathecal Catheter. Reg Anesth Pain Med; 34(6):600-602 Hamity MV, Whitea SR, Hammond DL: Effects of neurokinin-1 receptor agonism and antagonism in the rostral ventromedial medulla of rats with acute or persistent inflammatory nociception. Neuroscience Wachtel RE, Dexter F: Numerous studies have considered opportunity costs of operating time. Surgery Kasuya J, Kaas GA, Kitamoto T: A putative amino acid transporter of the solute carrier 6 family is upregulated by lithium and is required for resistance to lithium toxicity in Drosophila. Neuroscience; 163(3):825-37 Campos JH: An update on robotic thoracic surgery and anesthesia. Curr Opin Anaesthesiol
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The Department of Anesthesia at the University of Iowa is a leader in clinical and basic science research. Clinical investigations occur in all subspecialties including critical care and cardiothoracic, neurosurgical, and regional anesthesia. Basic science research topics are pain, analgesic pharmacology and learning and memory. There is an emphasis on training physicians and scientists on the fundamentals of basic and clinical research. The Department of Anesthesia is keenly interested in providing residents and fellows with the background for developing a career in research.
Surgical Intensive Care Unit Research
Operations Research
Pain Research
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| Grants Recently Awarded and Submitted |
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Grants Recently Awarded
| 12/2009 |
NIH, $1,687,500, Donna Hammond, PI, “Opioid Mechanisms of Analgesia.” |
| 09/2009 |
NIH, $1,380,000, Timothy Brennan, PI,“Nociception from Deep Muscle Incision.” |
| 09/2009 |
NIH, Timothy Brennan, Co-I, $91,575, “Complement System Modulation of Nociception and Inflammation after Incision.” |
| 09/2009 |
American Burn Association Grant, $25,000, Anthony Han, PI, “Clinical Pharmacology of Ketamine for Procedural Sedation in the Pediatric Burn Patients.” |
| 07/2009 |
NIH, $1,095,000, Toshihiro Kitamoto, PI, “Studies of Genes Involved in the Lithium Responsive Neurological Process.” |
| 07/2009 |
NIH T32, Donna Hammond, PI, “Interdisciplinary Training Program in Pain Research,” 4 trainee positions supported. |
Submitted Grants
| 11/2009 |
International Anesthesia Research Society (IARS), Anthony Han, PI, “Closed Loop Control of Intracranial Pressure: Development of a Novel Continuous Infusion Regimen for 20% Mannitol vs. 3% Hypertonic Saline.” |
| 11/2009 |
International Anesthesia Research Society (IARS), Joss Thomas, PI, “Iowa Outcomes with Anesthesia Adolescent Study (IOWAA Study).” |
| 10/2009 |
NIH K08, Christina Spofford, PI, “Acute Post Laminectomy Pain and Aging: Molecular Mechanisms.” |
| 10/2009 |
NIH R01, Bradley Hindman, PI, “Biomechanical Analysis and Modeling of Cervical Spine Motion during Intubation.” |
| 09/2009 |
NIH R01, Robert Block, PI, “General Anesthesia during Human Infancy and Brain Development.” |
| 08/2009 |
NIH/FDA, Children’s Hospital of Boston. Joss Thomas, Co-I, “A Multi-Site RCT Comparing Regional and General Anesthesia for Effects on Neurodevelopmental Outcome and Apnea in Infants: The GAS Study.” |
| 07/2009 |
March of Dimes, Joss Thomas, PI, “Iowa Outcomes with Anesthesia (IOWA) study.” |
| 06/2009 |
Anesthesia Patient Safety Foundation, Mazen Maktabi, PI, “An Epidemiological Study of Preoperative Cognitive Impairment as a Risk Factor for Postoperative Delirium Older Adults Undergoing Noncardiac Surgery.” |
| 06/2009 |
NIH ARRA Grant, James Bates, Co-I, Project 3 of PPG: “Cellular S-nitrosothiol Signaling in Respiratory Biology.” |
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| Investigator Spotlight: Max T. Baker, Ph.D. |
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 I received my doctorate in pharmacology at the University of Georgia College of Pharmacy studying the effects of dietary fats on carcinogen metabolic activation. After a postdoctoral fellowship at the Mayo Clinic, where I studied the metabolism of anesthetics and halogenated compounds by the cytochrome P450 enzyme system, I came to The University of Iowa in 1984. At the time, there was interest in the metabolism and toxicity of small fluorinated compounds as they were employed not only as anesthetics but as the new non-chlorinated refrigerant substitutes. Read more...
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