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James N. Bates, Ph.D., M.D.
Associate Professor


Contact Information
Job Description: Director, Obstetrical Anesthesia; Clinical Director, Main Operating Room
Office Address: 6416 JCP
Phone Number: (319) 356-2633

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Education
Graduate School
  • University of California at Santa Barbara
Postdoctoral Fellowship
  • The Salk Institute
Medical School
  • University of Miami
Internship in Internal Medicine
  • Southern Illinois University
Residency in Anesthesia
  • University of Iowa
Research Interests
  • Biochemistry of endogenous and exogenous nitrovasodilators
Appointments
  • The University of Iowa College of Medicine 1984-present
Publications
  1. Arkoosh VA, Palmer CM, Yun EM, Sharma SK, Bates JN, Wissler RN, Buxbaum JL, Nogami WM, Gracely EJ: A randomized, double-masked, multicenter comparison of the safety of continuous intrathecal labor analgesia using a 28-gauge catheter versus continuous epidural labor analgesia. Anesthesiology. 2008 Feb;108(2):286-98


  2. Lewis SJ, Hoque A, Sandock K, Robertson TP, Bates JN, Kooy NW: Differential effects of peroxynitrite on the function of arginine vasopressin V(1a) receptors and alpha(1)-adrenoceptors in vivo. Vascul Pharmacol 2007 Jan; 46: 24-34


  3. Hashmi-Hill MP, Sandock K, Bates JN, Robertson TP, Lewis SJ: Flavin Adenine Dinucleotide May Release Preformed Stores of Nitrosyl Factors From the Vascular Endothelium of Conscious Rats. J Cardiovasc Pharmacol 2007 Aug; 50(2):142-154


  4. Hashmi-Hill MP, Graves JE, Sandock K, Bates JN, Robertson TP, Lewis SJ: Hemodynamic Responses Elicited by Systemic Injections of Flavin Adenine Dinucleotide in Anesthetized Rats. J Cardiovasc Pharmacol 2007 Jul; 50(1):94-102


  5. Lewis SJ, Owen JR, Bates JN: S-nitrosocysteine elicits hemodynamic responses similar to those of the Bezold-Jarisch reflex via activation of stereoselective recognition sites. Eur J Pharmacol 2006 Jan; 531: 254-8


  6. Owen JR, Bates JN, Lewis SJ: Differential effects of nitroblue tetrazolium on the hemodynamic responses elicited by activation of alpha(1)-adrenoceptors and 5-HT2 receptors in conscious rats. Eur J Pharmacol 2006 Mar; 535: 248-52


  7. Whalen EJ, Bates JN, Johnson AK, Lewis SJ: Downregulation of propranolol-sensitive beta-adrenoceptor signaling after inhibition of nitric oxide synthesis. Br J Pharmacol 2006 Apr; 147: 755-64


  8. Lacolley PJ, Owen JR, Bates JN, Johnson AK, Lewis SJ: Tachyphylaxis to 5-HT3-receptor-mediated activation of vagal afferents is prevented by co-activation of 5-HT2 receptors. Brain Res 2006 Jun; 1093: 105-15


  9. Lewis SJ, Hashmi-Hill MP, Owen JR, Sandock K, Robertson TP, Bates JN: The vasodilator potency of the endothelium-derived relaxing factor, L-S-nitrosocysteine, is impaired in conscious spontaneously hypertensive rats. Vascul Pharmacol 2006 Jun; 44: 476-90


  10. Lewis SJ, Hashmi-Hill MP, Owen JR, Sandock K, Robertson TP, Bates JN: ACE inhibition restores the vasodilator potency of the endothelium-derived relaxing factor, L-S-nitrosocysteine, in conscious Spontaneously Hypertensive rats. Vascul Pharmacol 2006 Jun; 44: 491-507


  11. Lacolley P, Owen JR, Sandock K, Lewis TH, Bates JN, Robertson TP, Lewis SJ: 5-HT activates vagal afferent cell bodies in vivo: role of 5-HT(2) and 5-HT(3) receptors. Neuroscience 2006 Nov; 143: 273-287


  12. Lacolley P, Owen JR, Sandock K, Lewis TH, Bates JN, Robertson TP, Lewis SJ: Occipital artery injections of 5-HT may directly activate the cell bodies of vagal and glossopharyngeal afferent cell bodies in the rat. Neuroscience 2006 Nov; 143: 289-308


  13. Lewis SJ, Travis MD, Hashmi-Hill MP, Sandock K, Robertson TP, Bates JN: Differential effects of ouabain on the vasodilator actions of nitric oxide and S-nitrosothiols in vivo: Relevance to the identity of EDRF/EDHF. Vascul Pharmacol 2006 Dec; 45: 383-394


  14. Lewis SJ, Hoque A, Bates JN: Differentiation of L- and D-S-nitrosothiol recognition sites in vivo. J Cardiovasc Pharmacol 2005 Nov; 46(5):660-71


  15. Lewis SJ, Graves JE, Bates JN, Kooy NW: Peroxynitrite elicits dysfunction of stereoselective s-nitrosocysteine recognition sites. J Cardiovasc Pharmacol 2005 Nov; 46(5):637-45


  16. Hoque A, Owen JR, Bates JN, Lewis SJ: Effects of thiol chelation on alpha1-adrenoceptor-induced vasoconstriction in vivo. J Cardiovasc Pharmacol 2005 Nov; 46(5):627-36


  17. Owen JA, Bates JN, Lewis SJ: Endogenous nitrosyl factors may inhibit the desensitization of 5-HT3 receptors on vagal cardiopulmonary afferents. Brain Res 2005; 1059: 167-72


  18. Graves JE, Bates JN, Kooy NW, Lewis SJ: Vasodilator actions of the endothelium-derived relaxing factor L-S-nitrosocysteine in anaesthetized rats are markedly diminished by peroxynitrite. Clin Exp Pharmacol Physiol 2005 Dec; 32: 1137-41


  19. Lewis SJ, Bhopatkar MY, Walton TM, Bates JN: Role of voltage-sensitive calcium-channels in nitric oxide-mediated vasodilation in Spontaneously Hypertensive rats. Eur J Pharmacol 2005 Dec; 528: 144-9


  20. Davisson RL, Hoffmann DS, Butz GM, Aldape G, Schlager G, Merrill DC, Sethi S, Weiss RM, Bates JN: Discovery of a spontaneous genetic mouse model of preeclampsia. Hypertension 2002 Feb; 39(2 Pt 2):337-42


  21. Lee AG, Lipsky W, Bates JN, Grady F: Inadvertent retrobulbar administration of hypertonic saline prior to cataract extraction. J Cataract Refract Surg 2002 Jan; 28(1):192-4


  22. Travis MD, Hoque A, Bates JN, Lewis SJ: Blockade of voltage-sensitive Ca(2+)-channels markedly diminishes nitric oxide- but not L-S-nitrosocysteine- or endothelium-dependent vasodilation in vivo. Eur J Pharmacol 2000 Nov 24; 408(3):289-98


  23. Hoque A, Bates JN, Lewis SJ: Redox regulation of S-nitrosocysteine-mediated vasodilation in vivo. Eur J Pharmacol 2000 Nov 17; 408(2):195-8


  24. Hoque A, Bates JN, Lewis SJ: In vivo evidence that L-S-nitrosocysteine may exert its vasodilator effects by interaction with thiol residues in the vasculature. Eur J Pharmacol 1999 Nov 19; 384(2-3):169-72


  25. Massett MP, Lewis SJ, Bates JN, Kregel KC: Modulation of temperature-induced tone by vasoconstrictor agents. J Appl Physiol 1999 Mar; 86(3):963-9


  26. Massett MP, Lewis SJ, Bates JN, Kregel KC: Effect of heating on vascular reactivity in rat mesenteric arteries. J Appl Physiol 1998 Aug; 85(2):701-8


  27. Hindman BJ, Enomoto S, Dexter F, Bates JN, Aldape G, Cutkomp J, Smith T: Cerebrovascular relaxation responses to endothelium-dependent and -independent vasodilators after normothermic and hypothermic cardiopulmonary bypass in the rabbit. Anesthesiology 1998 Jun 24


  28. Li Z, Chapleau MW, Bates JN, Bielefeldt K, Lee HC, Abboud FM: Nitric oxide as an autocrine regulator of sodium currents in baroreceptor neurons. Neuron 1998 May; 20(5):1039-49


  29. George TN, Johnson KJ, Bates JN, Segar JL: The effect of inhaled nitric oxide therapy on bleeding time and platelet aggregation in neonates. J Pediatr 1998 Apr; 132(4):


  30. Travis MD, Davisson RL, Bates JN, Lewis SJ: Hemodynamic effects of L- and D-S-nitroso-beta,beta-dimethylcysteine in rats. Am J Physiol 1997 Sep; 273(3 Pt 2):


  31. Davisson RL, Travis MD, Bates JN, Johnson AK, Lewis SJ: Stereoselective actions of S-nitrosocysteine in central nervous system of conscious rats. Am J Physiol 1997 May; 272(5 Pt 2):


  32. Ohta H, Bates JN, Lewis SJ, Talman WT: Actions of S-nitrosocysteine in the nucleus tractus solitarii are unrelated to release of nitric oxide. Brain Res 1997 Jan 23; 746(1-2):


  33. Travis MD, Stoll LL, Bates JN, Lewis SJ: L- and D-S-nitroso-beta,beta-dimethylcysteine differentially increase cGMP in cultured vascular smooth muscle cells. Eur J Pharmacol 1996 Dec 27; 318(1):


  34. Davisson RL, Bates JN, Johnson AK, Lewis SJ: Use-dependent loss of acetylcholine- and bradykinin-mediated vasodilation after nitric oxide synthase inhibition. Evidence for preformed stores of nitric oxide-containing factors in vascular endothelial cells. Hypertension 1996 Sep; 28(3):


  35. Lewis SJ, Travis MD, Bates JN: Stereoselective S-nitrosocysteine recognition sites in rat brain. Eur J Pharmacol 1996 Sep 26; 312(2):


  36. Davisson RL, Travis MD, Bates JN, Lewis SJ: Hemodynamic effects of L- and D-S-nitrosocysteine in the rat. Stereoselective S-nitrosothiol recognition sites. Circ Res 1996 Aug; 79(2):


  37. Snyder GD, Holmes RW, Bates JN, Van Voorhis BJ: Nitric oxide inhibits aromatase activity: mechanisms of action. J Steroid Biochem Mol Biol 1996 Apr; 58(1):


  38. Matsuda T, Bates JN, Lewis SJ, Abboud FM, Chapleau MW: Modulation of baroreceptor activity by nitric oxide and S-nitrosocysteine. Circ Res 1995 Mar; 76(3):


  39. Vincent RD, Syrop CH, Van Voorhis BJ, Chestnut DH, Sparks AE, McGrath JM, Choi WW, Bates JN, Penning DH: An evaluation of the effect of anesthetic technique on reproductive success after laparoscopic pronuclear stage transfer. Propofol/nitrous oxide versus isoflurane/nitrous oxide. Anesthesiology 1995 Feb 1


  40. Thompson MW, Bates JN, Klein JM: Treatment of respiratory failure in an infant with bronchopulmonary dysplasia infected with respiratory syncytial virus using inhaled nitric oxide and high frequency ventilation. Acta Paediatr 1995 Jan 1


  41. Murray J, Bates JN, Conklin JL: Nerve-mediated nitric oxide production by opossum lower esophageal sphincter. Dig Dis Sci 1994 Sep; 39(9):


  42. Chestnut DH, McGrath JM, Vincent RD, Penning DH, Choi WW, Bates JN, McFarlane C: Does early administration of epidural analgesia affect obstetric outcome in nulliparous women who are in spontaneous labor? Anesthesiology 1994 Jun 1


  43. Chestnut DH, Vincent RD, McGrath JM, Choi WW, Bates JN: Does early administration of epidural analgesia affect obstetric outcome in nulliparous women who are receiving intravenous oxytocin? Anesthesiology 1994 Jun 1


  44. Kukreja RC, Wei EP, Kontos HA, Bates JN: Nitric oxide and S-nitroso-L-cysteine as endothelium-derived relaxing factors from acetylcholine in cerebral vessels in cats. Stroke 1993 Dec; 24(12):


  45. Conklin JL, Du C, Murray JA, Bates JN: Characterization and mediation of inhibitory junction potentials from opossum lower esophageal sphincter. Gastroenterology 1993 May; 104(5):


  46. Harrison DG, Bates JN: The nitrovasodilators. New ideas about old drugs. Circulation 1993 May; 87(5):


  47. Vincent RD, Chestnut DH, Choi WW, Ostman PL, Bates JN: Does epidural fentanyl decrease the efficacy of epidural morphine after cesarean delivery? Anesth Analg 1992 May 11


  48. Bates JN, Baker MT, Guerra R Jr, Harrison DG: Nitric oxide generation from nitroprusside by vascular tissue. Evidence that reduction of the nitroprusside anion and cyanide loss are required. Biochem Pharmacol 1991 Dec 11; 42 Suppl():S157-65


  49. Du C, Murray J, Bates JN, Conklin JL: Nitric oxide: mediator of NANC hyperpolarization of opossum esophageal smooth muscle. Am J Physiol 1991 Dec; 261(6 Pt 1):


  50. Murray J, Du C, Ledlow A, Bates JN, Conklin JL: Nitric oxide: mediator of nonadrenergic noncholinergic responses of opossum esophageal muscle. Am J Physiol 1991 Sep; 261(3 Pt 1):


  51. Lewis SJ, Ohta H, Machado B, Bates JN, Talman WT: Microinjection of S-nitrosocysteine into the nucleus tractus solitarii decreases arterial pressure and heart rate via activation of soluble guanylate cyclase. Eur J Pharmacol 1991 Sep 4; 202(1):


  52. Moy JA, Bates JN, Fisher RA: Effects of nitric oxide on platelet-activating factor- and alpha-adrenergic-stimulated vasoconstriction and glycogenolysis in the perfused rat liver. J Biol Chem 1991 May 5; 266(13):


  53. Rubanyi G, Johns A, Wilcox D, Bates JN, Harrison D. Evidence that a S-nitrosothiol, but not nitric oxide, may be identical with endothelium-derived relaxing factor. Journal of Cardiovascular Pharmacology 17: S41-S45, 1991


  54. Kurz MA, Lamping KG, Bates JN, Eastham CL, Marcus ML, Harrison DG: Mechanisms responsible for the heterogeneous coronary microvascular response to nitroglycerin. Circ Res 1991 Mar; 68(3):


  55. Bates JN, Harrison DG, Myers PR, Minor RL: EDRF: nitrosylated compound or authentic nitric oxide. Basic Res Cardiol 1991 Jan 1


  56. Minor RL Jr, Myers PR, Guerra R Jr, Bates JN, Harrison DG: Diet-induced atherosclerosis increases the release of nitrogen oxides from rabbit aorta. J Clin Invest 1990 Dec; 86(6):


  57. Meller ST, Lewis SJ, Bates JN, Brody MJ, Gebhart GF: Is there a role for an endothelium-derived relaxing factor in nociception? Brain Res 1990 Oct 29; 531(1-2):


  58. Baker MT, Vasquez MT, Bates JN, Chiang CK: Metabolism of 2-chloro-1,1-difluoroethene to glyoxylic and glycolic acid in rat hepatic microsomes. Drug Metab Dispos 1990 Sep 1


  59. Myers PR, Minor RL Jr, Guerra R Jr, Bates JN, Harrison DG: Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide. Nature 1990 May 10; 345(6271):


  60. Bates JN. Iron-59 labelled sodium nitroprusside. Journal of Labelled Compounds and Radiopharmaceuticals 28: 471-474, 1990


  61. Chestnut DH, Laszewski LJ, Pollack KL, Bates JN, Manago NK, Choi WW: Continuous epidural infusion of 0.0625% bupivacaine-0.0002% fentanyl during the second stage of labor. Anesthesiology 1990 Apr 1


  62. Sellke FW, Myers PR, Bates JN, Harrison DG: Influence of vessel size on the sensitivity of porcine coronary microvessels to nitroglycerin. Am J Physiol 1990 Feb; 258(2 Pt 2):


  63. Chestnut DH, Owen CL, Geiger M, Bates JN, Choi WW, Ostman PL: Metoclopramide versus droperidol for prevention of nausea and vomiting during epidural anesthesia for cesarean section. South Med J 1989 Oct 1


  64. Chestnut DH, Geiger M, Bates JN, Choi WW: The influence of pH-adjusted 2-chloroprocaine on the quality and duration of subsequent epidural bupivacaine analgesia during labor: a randomized, double-blind study. Anesthesiology 1989 Mar 1


  65. Chestnut DH, Owen CL, Bates JN, Ostman LG, Choi WW, Geiger MW: Continuous infusion epidural analgesia during labor: a randomized, double-blind comparison of 0.0625% bupivacaine/0.0002% fentanyl versus 0.125% bupivacaine. Anesthesiology 1988 May 1


  66. Baker MT, Bates JN: Metabolic activation of the halothane metabolite, [14C]2-chloro-1,1-difluoroethene, in hepatic microsomes. Drug Metab Dispos 1988 Mar 1


  67. Baker MT, Bates JN, Leff SV: Stimulatory effects of halothane and isoflurane on fluoride release and cytochrome P-450 loss caused by metabolism of 2-chloro-1,1-difluoroethene, a halothane metabolite. Anesth Analg 1987 Nov 1


  68. Baker MT, Bates JN, Leff SV: Comparative defluorination and cytochrome P-450 loss by the microsomal metabolism of fluoro- and fluorochloroethenes. Drug Metab Dispos 1987 Jul 1


  69. Chestnut DH, Vandewalker GE, Owen CL, Bates JN, Choi WW: The influence of continuous epidural bupivacaine analgesia on the second stage of labor and method of delivery in nulliparous women. Anesthesiology 1987 Jun; 66(6):


  70. Chestnut DH, Vandewalker GE, Owen CL, Bates JN, Choi WW: Administration of metoclopramide for prevention of nausea and vomiting during epidural anesthesia for elective cesarean section. Anesthesiology 1987 Apr; 66(4):


  71. Baker MT, Bates JN, Van Dyke RA: Stabilization of the reduced halocarbon-cytochrome P-450 complex of halothane by N-alkanes. Biochem Pharmacol 1987 Apr 1; 36(7):1029-34


  72. Chestnut DH, Bates JN, Choi WW: Effect of intravenous administration of Ringer's lactate on maternal capillary blood glucose before elective cesarean section. J Reprod Med 1987 Mar; 32(3):


  73. Chestnut DH, Bates JN, Choi WW: Continuous infusion epidural analgesia with lidocaine: efficacy and influence during the second stage of labor. Obstet Gynecol 1987 Mar; 69(3 Pt 1):
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