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Donna L. Hammond, Ph.D.
Professor


Contact Information
Job Description: Interim Head, Department of Pharmacology
Office Address: 6505-2 JCP
Phone Number: (319) 384-7127

Email Me

Education
Ph.D.
  • University of Illinois at Chicago
Organizations
  • Society for Neuroscience, American Pain Society, International Association for the Study of Pain
Appointments
  • Anesthesia; Pharmacology
Publications
  1. Aldrich BT, Frakes EP, Kasuya J, Hammond DL, Kitamoto T: Changes in expression of sensory organ-specific microRNAs in rat dorsal root ganglia in association with mechanical hypersensitivity induced by spinal nerve ligation. Neuroscience 2009 Dec 1


  2. Hamity MV, Whitea SR, Hammond DL: Effects of neurokinin-1 receptor agonism and antagonism in the rostral ventromedial medulla of rats with acute or persistent inflammatory nociception. Neuroscience 2009 Nov 3


  3. Zhang L, Hammond DL: Substance P enhances excitatory synaptic transmission on spinally projecting neurons in the rostral ventromedial medulla after inflammatory injury. J Neurophysiol 2009 Jun 6


  4. Sykes KT, White SR, Hurley RW, Mizoguchi H, Tseng LF, Hammond DL: Mechanisms responsible for the enhanced antinociceptive effects of micro-opioid receptor agonists in the rostral ventromedial medulla of male rats with persistent inflammatory pain. J Pharmacol Exp Ther 2007 May 15


  5. Zhang L, Jongeling AC, Hammond DL: Suitability of the retrograde tracer Dil for electrophysiological studies of brainstem neurons: adverse ramifications for G-protein coupled receptor agonists. J Neurosci Methods 2007 Feb 15


  6. Zhang L, Sykes KT, Buhler AV, Hammond DL: Electrophysiological heterogeneity of spinally projecting serotonergic and nonserotonergic neurons in the rostral ventromedial medulla. J Neurophysiol 2005 Dec 13


  7. Hammond DL, Ackerman L, Holdsworth R, Elzey B: Effects of spinal nerve ligation on immunohistochemically identified neurons in the L4 and L5 dorsal root ganglia of the rat. J Comp Neurol 2004 Aug 2


  8. Parra MC, Nguyen TN, Hurley RW, Hammond DL: Persistent inflammatory nociception increases levels of dynorphin 1-17 in the spinal cord, but not in supraspinal nuclei involved in pain modulation. J Pain 2003 Nov 19


  9. Naguib M, Hammond DL, Schmid PG, Baker MT, Cutkomp J, Queral L, Smith T: Pharmacological effects of intravenous melatonin: comparative studies with thiopental and propofol. Br J Anaesth 2003 Mar 20


  10. Hurley RW, Banfor P, Hammond DL: Spinal pharmacology of antinociception produced by microinjection of mu or delta opioid receptor agonists in the ventromedial medulla of the rat. Neuroscience 2003; 118(3):789-96


  11. Hurley RW, Chatterjea D, Rose Feng M, Taylor CP, Hammond DL: Gabapentin and Pregabalin Can Interact Synergistically with Naproxen to Produce Antihyperalgesia. Anesthesiology 2002 Nov; 97(5):1263-1273


  12. Hammond DL: GABA(B) receptors: new tricks by an old dog. Curr Opin Pharmacol 2001 Nov 20


  13. Hammond DL: J.J. Bonica Lecture--2001: role of spinal GABA in acute and persistent nociception. Reg Anesth Pain Med 2001 Nov 15


  14. Oh SB, Tran PB, Gillard SE, Hurley RW, Hammond DL, Miller RJ: Chemokines and glycoprotein120 produce pain hypersensitivity by directly exciting primary nociceptive neurons. J Neurosci 2001 Jul 15; 21(14):5027-35


  15. Hurley RW, Hammond DL: Contribution of endogenous enkephalins to the enhanced analgesic effects of supraspinal mu opioid receptor agonists after inflammatory injury. J Neurosci 2001 Apr 1; 21(7):2536-45


  16. Ugarte SD, Homanics GE, Firestone LL, Hammond DL: Sensory thresholds and the antinociceptive effects of GABA receptor agonists in mice lacking the beta3 subunit of the GABA(A) receptor. Neuroscience 2000 March; 95(3):795-806


  17. Hurley RW, Hammond DL: The analgesic effects of supraspinal mu and delta opioid receptor agonists are potentiated during persistent inflammation. J Neurosci 2000 Feb 1; 20(3):1249-59


  18. Kaneko M, Mestre C, Sanchez EH, Hammond DL: Intrathecally administered gabapentin inhibits formalin-evoked nociception and the expression of Fos-like immunoreactivity in the spinal cord of the rat. J Pharmacol Exp Ther 2000 Feb; 292(2):743-51


  19. Grabow TS, Hurley RW, Banfor PN, Hammond DL: Supraspinal and spinal delta(2) opioid receptor-mediated antinociceptive synergy is mediated by spinal alpha(2) adrenoceptors. Pain 1999 Oct; 83(1):47-55


  20. Hurley RW, Grabow TS, Tallarida RJ, Hammond DL: Interaction between medullary and spinal delta1 and delta2 opioid receptors in the production of antinociception in the rat. J Pharmacol Exp Ther 1999 May; 289(2):993-9


  21. Hammond DL, Kaneko M, Mestre C: Pharmacological and neuroanatomical studies of the antinociceptive effects of intrathecally administered gabapentin. Masui 1998 Dec; 47 Suppl():S229-30


  22. John JM, Kaneko M, Hammond DL: Intrathecal bicuculline does not increase formalin-induced inflammation. Brain Res 1998 Jun 1; 794(2):320-4


  23. Hammond DL, Nelson V, Thomas DA: Intrathecal methysergide antagonizes the antinociception, but not the hyperalgesia produced by microinjection of baclofen in the ventromedial medulla of the rat. Neurosci Lett 1998 Mar 13; 244(2):93-6


  24. Hammond DL, Wang H, Nakashima N, Basbaum AI: Differential effects of intrathecally administered delta and mu opioid receptor agonists on formalin-evoked nociception and on the expression of Fos-like immunoreactivity in the spinal cord of the rat. J Pharmacol Exp Ther 1998 Jan; 284(1):378-87


  25. Thorat SN, Hammond DL: Modulation of nociception by microinjection of delta-1 and delta-2 opioid receptor ligands in the ventromedial medulla of the rat. J Pharmacol Exp Ther 1997 Dec; 283(3):1185-92


  26. Graham BA, Hammond DL, Proudfit HK: Differences in the antinociceptive effects of alpha-2 adrenoceptor agonists in two substrains of Sprague-Dawley rats. J Pharmacol Exp Ther 1997 Nov; 283(2):511-9


  27. Hammond DL, Donahue BB, Stewart PE: Role of spinal delta1 and delta2 opioid receptors in the antinociception produced by microinjection of L-glutamate in the ventromedial medulla of the rat. Brain Res 1997 Aug 8; 765(1):177-81


  28. Hama AT, Fritschy JM, Hammond DL: Differential distribution of (GABA)A receptor subunits on bulbospinal serotonergic and nonserotonergic neurons of the ventromedial medulla of the rat. J Comp Neurol 1997 Aug 4; 384(3):337-48


  29. Kaneko M, Hammond DL: Role of spinal gamma-aminobutyric acidA receptors in formalin-induced nociception in the rat. J Pharmacol Exp Ther 1997 Aug; 282(2):928-38


  30. Mason P, Owens CA, Hammond DL: Antagonism of the antinocifensive action of halothane by intrathecal administration of GABAA receptor antagonists. Anesthesiology 1996 May; 84(5):1205-14


  31. Thomas DA, Navarrete IM, Graham BA, McGowan MK, Hammond DL: Antinociception produced by systemic R(+)-baclofen hydrochloride is attenuated by CGP 35348 administered to the spinal cord or ventromedial medulla of rats. Brain Res 1996 Apr 29; 718(1-2):129-37


  32. McKinzie SL, Hammond DL, Grabau C, Tyce GM: Releases of norepinephrine and dopamine in ventriculocisternal perfusions in hepatectomized and laparotomized rats. J Neurochem 1996 Feb; 66(2):569-78


  33. Thomas DA, Hammond DL: Microinjection of morphine into the rat medullary dorsal horn produces a dose-dependent increase in facial scratching. Brain Res 1995 Oct 16; 695(2):267-70


  34. Thomas DA, McGowan MK, Hammond DL: Microinjection of baclofen in the ventromedial medulla of rats: antinociception at low doses and hyperalgesia at high doses. J Pharmacol Exp Ther 1995 Oct; 275(1):274-84


  35. Hammond DL, Stewart PE, Littell L: Antinociception and delta-1 opioid receptors in the rat spinal cord: studies with intrathecal 7-benzylidenenaltrexone. J Pharmacol Exp Ther 1995 Sep; 274(3):1317-24


  36. Glaum SR, Miller RJ, Hammond DL: Inhibitory actions of delta 1-, delta 2-, and mu-opioid receptor agonists on excitatory transmission in lamina II neurons of adult rat spinal cord. J Neurosci 1994 Aug; 14(8):4965-71


  37. Stewart PE, Holper EM, Hammond DL: Delta antagonist and kappa agonist activity of Naltriben: evidence for differential kappa interaction with the delta 1 and delta 2 opioid receptor subtypes. Life Sci 1994 August; 55(4):PL79-84


  38. Pitzele BS, Hamilton RW, Kudla KD, Tsymbalov S, Stapelfeld A, Savage MA, Clare M, Hammond DL, Hansen DW Jr: Enkephalin analogs as systemically active antinociceptive agents: O- and N-alkylated derivatives of the dipeptide amide L-2,6-dimethyltyrosyl-N-(3-phenylpropyl)-D-alaninamide. J Med Chem 1994 Apr 1; 37(7):888-96


  39. Stewart PE, Hammond DL: Activation of spinal delta-1 or delta-2 opioid receptors reduces carrageenan-induced hyperalgesia in the rat. J Pharmacol Exp Ther 1994 Feb; 268(2):701-8


  40. Hammond DL, Stapelfeld A, Drower EJ, Savage MA, Tam L, Mazur RH: Antinociception produced by oral, subcutaneous or intrathecal administration of SC-39566, an opioid dipeptide arylalkylamide, in the rodent. J Pharmacol Exp Ther 1994 Feb; 268(2):607-15


  41. McGowan MK, Hammond DL: Antinociception produced by microinjection of L-glutamate into the ventromedial medulla of the rat: mediation by spinal GABAA receptors. Brain Res 1993 Aug 20; 620(1):86-96


  42. Stewart PE, Hammond DL: Evidence for delta opioid receptor subtypes in rat spinal cord: studies with intrathecal naltriben, cyclic[D-Pen2, D-Pen5] enkephalin and [D-Ala2, Glu4]deltorphin. J Pharmacol Exp Ther 1993 Aug; 266(2):820-8


  43. Hammond DL, Washington JD: Antagonism of L-baclofen-induced antinociception by CGP 35348 in the spinal cord of the rat. Eur J Pharmacol 1993 Apr 6; 234(2-3):255-62


  44. McGowan MK, Hammond DL: Intrathecal GABAB antagonists attenuate the antinociception produced by microinjection of L-glutamate into the ventromedial medulla of the rat. Brain Res 1993 Apr 2; 607(1-2):39-46


  45. Hammond DL, Bloss JL: Antinociceptive effects of SC-39566, an opioid dipeptide arylalkylamide, in the Rhesus monkey. Eur J Pharmacol 1993 Feb 9; 231(2):281-5


  46. Hammond DL, Moy ML: Actions of 4-amino-3-(5-methoxybenzo(b)furan-2-yl) butanoic acid and 4-amino-3-benzo(b)furan-2-yl butanoic acid in the rat spinal cord. Eur J Pharmacol 1992 Dec 15; 229(2-3):227-34


  47. Stapelfeld A, Hammond DL, Rafferty MF: Antinociception after intracerebroventricular administration of naltrindole in the mouse. Eur J Pharmacol 1992 Apr 22; 214(2-3):273-6


  48. Hansen DW Jr, Stapelfeld A, Savage MA, Reichman M, Hammond DL, Haaseth RC, Mosberg HI: Systemic analgesic activity and delta-opioid selectivity in [2,6-dimethyl-Tyr1,D-Pen2,D-Pen5]enkephalin. J Med Chem 1992 Feb 21; 35(4):684-7


  49. Hammond DL, Presley R, Gogas KR, Basbaum AI: Morphine or U-50,488 suppresses Fos protein-like immunoreactivity in the spinal cord and nucleus tractus solitarii evoked by a noxious visceral stimulus in the rat. J Comp Neurol 1992 Jan 8; 315(2):244-53


  50. Drower EJ, Stapelfeld A, Rafferty MF, de Costa BR, Rice KC, Hammond DL: Selective antagonism by naltrindole of the antinociceptive effects of the delta opioid agonist cyclic[D-penicillamine2-D-penicillamine5]enkephalin in the rat. J Pharmacol Exp Ther 1991 Nov; 259(2):725-31


  51. Hammond DL, Ruda MA: Developmental alterations in nociceptive threshold, immunoreactive calcitonin gene-related peptide and substance P, and fluoride-resistant acid phosphatase in neonatally capsaicin-treated rats. J Comp Neurol 1991 Oct 15; 312(3):436-50


  52. Aran S, Hammond DL: Antagonism of baclofen-induced antinociception by intrathecal administration of phaclofen or 2-hydroxy-saclofen, but not delta-aminovaleric acid in the rat. J Pharmacol Exp Ther 1991 Apr; 257(1):360-8


  53. Hammond DL: Neurochemical, neuroendocrine, and immunologic measures in the diagnosis and treatment of chronic pain. Anesth Prog 1990 Mar-Jun; 37(2-3):106-7


  54. Bloss JL, Hammond DL: Intermittent shock titration task in the rhesus monkey and its validity as an analgesiometric procedure. Brain Res 1989 Oct 16; 499(2):344-56


  55. Hammond DL, Ruda MA: Developmental alterations in thermal nociceptive threshold and the distribution of immunoreactive calcitonin gene-related peptide and substance P after neonatal administration of capsaicin in the rat. Neurosci Lett 1989 Feb 13; 97(1-2):57-62


  56. Drower EJ, Hammond DL: GABAergic modulation of nociceptive threshold: effects of THIP and bicuculline microinjected in the ventral medulla of the rat. Brain Res 1988 May 31; 450(1-2):316-24


  57. Hammond DL: Intrathecal administration: methodological considerations. Prog Brain Res 1988 March; 77():313-20


  58. Drower EJ, Stapelfeld A, Mueller RA, Hammond DL: The antinociceptive effects of prostaglandin antagonists in the rat. Eur J Pharmacol 1987 Jan 20; 133(3):249-56


  59. Bloss JL, Hammond DL: Shock titration in the rhesus monkey: effects of opiate and nonopiate analgesics. J Pharmacol Exp Ther 1985 Nov; 235(2):423-30


  60. Barbaro NM, Hammond DL, Fields HL: Effects of intrathecally administered methysergide and yohimbine on microstimulation-produced antinociception in the rat. Brain Res 1985 Sep 23; 343(2):223-9


  61. Hammond DL, Tyce GM, Yaksh TL: Efflux of 5-hydroxytryptamine and noradrenaline into spinal cord superfusates during stimulation of the rat medulla. J Physiol (Lond) 1985 Feb; 359():151-62


  62. Hammond DL, Drower EJ: Effects of intrathecally administered THIP, baclofen and muscimol on nociceptive threshold. Eur J Pharmacol 1984 Aug 3; 103(1-2):121-5


  63. Hammond DL, Yaksh TL, Tyce GM: Conjugates of dopamine and serotonin in ventriculocisternal perfusates of the cat. J Neurochem 1984 Jun; 42(6):1752-7


  64. Hammond DL, Yaksh TL: Antagonism of stimulation-produced antinociception by intrathecal administration of methysergide or phentolamine. Brain Res 1984 Apr 30; 298(2):329-37


  65. Bergstrom L, Hammond DL, Go VL, Yaksh TL: Concurrent measurement of substance P and serotonin in spinal superfusates: failure of capsaicin and p-chloroamphetamine to co-release. Brain Res 1983 Jun 27; 270(1):181-4


  66. Schmauss C, Hammond DL, Ochi JW, Yaksh TL: Pharmacological antagonism of the antinociceptive effects of serotonin in the rat spinal cord. Eur J Pharmacol 1983 Jun 17; 90(4):349-57


  67. Hammond DL, Tyce GM, Yaksh TL: Drug-induced alterations in the efflux of 5-hydroxytryptamine and of 5-hydroxyindoleacetic acid into superfusates of the rat spinal cord. Eur J Pharmacol 1983 Mar 4; 87(4):441-8


  68. Yaksh TL, Hammond DL: Peripheral and central substrates involved in the rostrad transmission of nociceptive information. Pain 1982 May; 13(1):1-85


  69. Yaksh TL, Hammond DL, Tyce GM: Functional aspects of bulbospinal monoaminergic projections in modulating processing of somatosensory information. Fed Proc 1981 Nov; 40(13):2786-94


  70. Hammond DL, Yaksh TL, Tyce GM: Presence of conjugated 5-hydroxytryptamine in in vivo superfusates of rat spinal cord. J Neurochem 1981 Oct; 37(4):1068-71


  71. Proudfit HK, Hammond DL: Alterations in nociceptive threshold and morphine-induced analgesia produced by intrathecally administered amine antagonists. Brain Res 1981 Aug 10; 218(1-2):393-9


  72. Hammond DL, Yaksh TL: Peripheral and central pathways in pain. Pharmacol Ther 1981 January; 14(3):459-75


  73. Hammond DL, Levy RA, Proudfit HK: Hypoalgesia induced by microinjection of a norepinephrine antagonist in the raphe magnus: reversal by intrathecal administration of a serotonin antagonist. Brain Res 1980 Nov 17; 201(2):475-9


  74. Hammond DL, Levy RA, Proudfit HK: Hypoalgesia following microinjection of noradrenergic antagonists in the nucleus raphe magnus. Pain 1980 Aug; 9(1):85-101


  75. Hammond DL, Proudfit HK: Effects of locus coeruleus lesions on morphine-induced antinociception. Brain Res 1980 Apr 21; 188(1):79-91
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