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Anthony Tae Hyung Han, MD, PhD.
Associate Professor


Contact Information
Office Address: 6505 JCP
Phone Number: (319) 384-5772

Email Me

Education
Fellowship in Pain Management
  • University of Marland Medical Center
Residency in Anesthesiology
  • University of MIssissippi Medical Center
Residency in Family Medicine
  • University of Tennessee, St. Francis Medical Center
PhD in Electrophysiology
  • Catholic University Graduate School of Medicine
MS in Anesthesiology
  • Catholic University Graduate School of Medicine
MD
  • Seoul National University College of Medicine
BS
  • Seoul National University College of Medicine
Research Interests
  • NONMEM for population pharmacokinetics and pharmacodynamics
  • Target controlled infusion of anesthetic agents, Pharmacogenomics
  • Special expertise in clinical pharmacology and therapeutics in patients with major burns and trauma, systemic inflammation and sepsis, and critical care.
  • Ketamine Pharmacokinetics for Sedation and Analgesia in Children with Burn Injury Undergoing Frequent Dressing Changes in the Burn Care Unit
  • Comparative Pharmacokinetics and Pharmacodynamics of Hyperosmotic Agents (Mannitol and Hypertonic Saline) in Patients Undergoing Neurosurgical Procedure
  • Minimal stimulating threshold in patients with long standing diabetes and chronic renal failure
  • Sub-anesthetic Ketamine Infusion for Sedation and Analgesia after Off-Pump Cardiac Surgery in the Surgical Intensive Care Unit
Awards
  • The 3rd Place Physician Paper, Midwestern Region Burns Conference, Minneapolis/ St. Paul, Minnesota. September 20-21, 2007
  • Scientific Poster Recognition Award, Midwestern Region Burns Conference, Minneapolis/ St. Paul, Minnesota. September 20-21, 2007
  • The 1st Place Winner, Photography, Art Exhibition, American Society of Anesthesiologists (2006)
  • Award of Excellence of Scientific Presentation, Korean Society of Intravenous Anesthesia (2006)
  • The 2nd Place Winner, Photography, Art Exhibition, American Society of Anesthesiologists (2005)
  • Arrow Award of Excellence in Academic Research, Korean Society of Anesthesiologists (2005)
  • Abbott Young Investigator Awards, Korean Society of Anesthesiologists (2004)
  • Best MD Paper, Midwestern Region Burn Conference,Omaha, Nebraska, 2008
Organizations
  • Johnson County Medical Society
  • Iowa State Medical Society
  • Iowa Society of Family Physician
  • American Medical Association
  • American Academy of Family Physician
  • American Society of Anesthesiologists
  • American Society of Regional Anesthesia and Pain Medicine
  • American Society of Pain Medicine
  • American Burn Association
  • International Association for Study of Pain
  • International Society for Anesthetic Pharmacology
  • International Society for Burn Injuries
  • Internation Anesthesia Research Society
Appointments
  • Associate Professor, Department of Anesthesia, University of Iowa Hospitals and Clinics, Carver College of Medicine
  • Professor, Department of Anesthesiology and Pain Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine
  • Associate Professor, Department of Anesthesiology and Pain Medicine, Hangang Sacred Heart Hospital, Hallym University College of Medicine
  • Assistant Professor, Department of Anesthesiology, Samsung Medical Center, SungKyunKwan University School of Medicine
  • Instructor, Department of Anesthesiology, Samsung Medical Center, SungKyunKwan University School of Medicine
  • Instructor, Department of Anesthesiology, University of Maryland Medical Center College of Medicine
Additional

GRANTS

Pending Grants

Low Molecular Weight Heparin for DVT prophylaxis in Patients with Major Burns---Recovery Act Research Support, NIH. PI.

 

Active Grants

Population Pharmacokinetics and Pharmacodynamics of Ketamine for Procedural Sedation in Children with Major Burns:  Phase 1 of a Pilot Study to Determine Rational Dosing Guidelines.

International Association of Fire Fighters Burn Foundation.  $24,400.  04/2009 PI.

 
Phase II Randomized, Double-Blind, Placebo-Controlled Multicenter Efficacy and Safety Study of Tanezumab as Add-on Therapy to Opioid Medication in Patients with Pain due to Bone Metastasis. Protocol number: A4091003 Pfizer 2009
                                                              
Phase 2 Open-Labeled Safety Extension Study of Tanezumab in Cancer Patients with Pain due to Bone Metastasis     Protocol number A4091029 Pfizer 2009
 
Clinical Trial Center Development Project Utilizing Pharmacokinetics, Pharmacodynamics and Pharmacogenomics. Grant Number A06-0093-B41104-06N1-00040B.  Korean Health Industry Development Institute. $210,000.  2006-2011. Co-PI.

 

Completed Grants

1. A multi-center double-blind placebo-controlled study to evaluate the efficacy and safety of Lenalinomide in the treatment of complex regional pain syndrome, type I. Celgene $132,213 00/00/2005 Co-PI.

 

2. A phase III, randomized, double blind, placebo controlled, two-arm parallel , multicenter study evaluating efficacy and safety of dexmedetomidine in the prevention of postoperative  delirium in subject undergoing for fractured hip with general anesthesia. (On Hold) Hospira 07/ 2007 Co-Sub PI.

 
3. Protocol #ELN92045-501: An open-label, long-term, multi-center, intrathecal Ziconotide (Prialt) effectiveness and safety trial (ZEST) in patients with chronic severe pain. Elan Pharmaceuticals $15,750. 06/04. Co-PI.

 

4. The Pharmacokinetics of Propofol in Major Burn Patients undergoing Extensive Burn Surgery.

Grant Number E00070, Outstanding Female Scientists Research Support Project, Korean Research Foundation. $17,500. 2005 Co-PI.

 

5. Development of PCB Based Rapid Fluid and Blood Warmer. Grant Number A050822, Korean Health Industry Development Institute. $100,000. 2005 Co-PI.

 

6. Alterations of Human Muscle Nicotinic Acetylcholine Receptor Subtypes in Major Burns Grant Number 01-2005-03, Il Song Research Institute, Hallym Medical Center $ 10,000. 2005 Co-PI.

 

7. The Pharmacokinetics of Fentanyl in Major Burn Patients undergoing Extensive Burn Surgery

Grant Number 01-2004-03, Il Song Research Institute, Hallym Medical Center $ 10,000. 2004 Co-PI.

 

8. The endotoxin, adhesion molecule and cytokine kinetics of early escharectomy in major burn patients Grant Number 01-2003-01, Il Song Research Institute, Hallym Medical Center $ 10,000. 2003 PI.

 

9. Onset time and duration of action of rocuronium induced neuromuscular blockade in major burn patients. The Organon, Inc. $5,000. 2002 PI.

 

10. The pharmacologic effect of meloxicam and codeine combination analgesics in experimental rats. Grant Number 01-2002-01, Il Song Research Institute, Hallym Medical Center $ 10,000. 2002 PI.

 
PUBLICATIONS
1. Han TH, Park CS: The analgesic efficacy and side effects of subarachnoid sufentanil-bupivacaine on parturients in advanced labor.  Korean J Perinatol 1996; 7: 414-421.
 

2. Han TH, Kang JW, Hong JJ, Shin BH:  Comparison of patient controlled analgesia after gynecological surgery requiring lower abdominal incision: Eptazocine vs. morphine.  J Korean Pain Res Soc 1996; 6: 46-53.

 

3. Kim MH, Kim YH, Han TH, Shin BH:  Intracellular calcium alterations induced during reperfusion injury are altered by local anesthetics and hypothermia.  Korean J Anesthesiol 1996; 30: 392-400.

 

4. Han TH, Lee JJ, Kang JW, Shin BH:  Comparison of butorphanol and morphine patient controlled analgesia after gynecological surgery.  Korean J Anesthesiol 1996; 31: 254-261.

 

5. Lee JJ, Han TH, Shin BH:  Paresthesia and motor weakness of left shoulder after interscalene nerve block.  Korean J Anesthesiol 1996; 31: 802-806.

 

6. Han TH, Kim YH:  The effect of nonsteroidal anti-inflammatory agent on morphine patient controlled analgesia in acute pain management.  J Korean Soc Intravenous Anesthesia 1997; 1: 105-112.

 

7. Han TH, Hwang WG:  Propofol as an adjuvant in the treatment of cancer related pain.  J Korean Pain Soc 1997; 10: 117-120.

 

8. Han TH, Cho YS:  The analgesic efficacy and side effects of subarachnoid sufentanil-bupivacaine on parturients in advanced labor.  J Korean Pain Soc 1997; 10: 21-27.

 

9. Han TH, Seo JW, Shin BH, Son JC:  The effect of postoperative propacetamol on acute pain and endocrine-metabolic response in gynecological surgery.  J Korean Pain Soc 1997; 10: 170-178.

 

10. Byeon JJ, Han TH:  Inappropriate drug prescription for the patients who visits two or more doctors.  J Korean Acad Family Med 1997; 18: 927-935.

 

11. Lee JJ, Jeon WJ, Kim CS, Kim GS, Ham TS, Cho HS, Han TH, Shin BH:  Pulmonary function changes during spinal anesthesia: Bupivacaine vs. tetracaine.  Korean J Anesthesiol 1997; 33: 1109-1115.

 

12. Han TH, Park CS:  The morphine sparing effect of propacetamol on patient controlled analgesia in gynecological surgery.  Korean J Ob Gyn 1997; 40: 261-268.

 

13. Han TH, Shin BS, Kim JH:  Pain control after dental surgery: Myprodol vs. Ibuprofen vs. Codeine.  J Korean Pain Soc 1998; 11: 74-80.

 

14. Han TH, Hwang WG, Lim OW, Shin BH:  The prophylactic effect of preoperative ondansetron for postoperative nausea and vomiting.  J Korean Soc Intravenous Anesthesia 1998; 2: 270-275.

 

15. Han TH, Eun JS, Lee SM, Shin BH:  Paroxetine, a selective serotonin reuptake inhibitor for neuropathic pain syndromes.  J Korean Pain Soc 1998; 11: 201-209.

 

16. Han TH, Soo RL, Shin BH:  Dexamethasone treatment of bone pain in metastatic prostate cancer: Assessment of pain indicies and quality of life.  Korean J Anesthesiol 1998; 34: 394-402.

 

17. Lee SM, Han TH, Kang YJ, Hwang WG, Lee JJ, Shin BH:  The radiological measurement of cervical spine extension during Bullard or direct laryngoscopy.  Korean J Anesthesiol 1998; 35: 890-894.

 
18. Kim MH, Kim JK, Han TH, Park JD, Shin BH, Lee BD, Kim YH:  The effects of oral clonidine on the cytokines and stress hormone responses in patients undergoing abdominal hysterectomy.  Korean J Anesthesiol 1998; 35; 327-333.

 

19. Han TH, Eun JS, Choi YS, Kim MH, Shin BH, Noh JH, Kim SN:  The effects of stomach cancer surgery on immunomodulation and neuroendocrine response: Comparison of anesthesia and analgesia method.  Korean J Anesthesiol 1998; 34: 1036-1045.

 

20. Han TH:  Current concept in anesthetic management of cancer pain management. Editorial.  J Korean Pain Research Society 1999; 9: 10-20.

 

21. Han TH, Lee YN, Shin BH:  The comparison of dose related efficacy and side effects of intrathecal sufentanil in labor analgesia.  Korean J Anesthesiol 1999; 37: 254-261

 

22. Kil HY, Whang SM, Lee SJ, Kim DW, Han TH, Park YJ:  Comparison of context sensitive half time with propofol infusion time and alertness using PK-SIM computer simulation during Propofol-N2O-O2 anesthesia.  J Korean Soc Intravenous Anesthesia 1999; 3: 92-98.

 

23. Kil HY, Lee SI, Lee SJ, Park YJ, Kim DW, Han TH, Soon Im Kim:  A case of total intravenous anesthesia using propofol-fentanyl computer assisted continuous infusion.  Korean J Anesthesiol 1999; 37: 516-521.

 

24. Kil HY, Lee SI, Choli YH, Lee SJ, Park YJ, Han TH, Kim DW:  Hypnotic dose response of etomidate using a bispectral index during anesthesia induction,  Korean J Anesthesiol 1999; 37: 580-587.

 

25. Soo RL, Kang HM, Han TH:  Can different analgesic methods affect open thoracotomy outcomes?  Korean J Anesthesiol 1999; 37: 668 � 674.

 

26. Kim HS, Han TH, Kim KM:  Epidurographical spreading patterns of successive small volume caudal epidural injections in chronic low back pain.  Korean J Anesthesiol 2000; 39: S12-16.

 

27. Han TH, Kwon MA:  Gabapentin as an adjuvant analgesic in central pain syndrome.  Korean J Anesthesiol 2000; 39: 821-828.

 

28. Han TH, Yeo JS, Sung DH:  The clinical effect of selective cyclooxygenase inhibitor meloxicam in chronic osteoarthritis.  Korean J Anesthesiol 2000; 39: 829-835.

 

29. Kim HS, Choi KH, Han TH:  IV ketorolac combined with morphine PCA in postoperative pain control after lumbar disc surgery.  J of Korean Pain Society 2000; 13: 218-223.

 

30. Han TH, Kwon MA:  The opioid sparing effects of ketorolac in terminal cancer pain management.  Korean J Anesthesiol 2000; 39: 98-103.

 

31. Han TH:  The effect of chemical lumbar sympathetic neurolysis in peripheral arterial occlusive disease: Buerger's disease vs. arteriosclerosis obliterans.  Korean J Anesthesiol 2000; 38: 432-439.

 

32. Han TH, Lee DI, Lee SC, Lee YW:  Gabapentin for the management of various neuropathic pain syndromes.  J Korean Pain Soc 2000; 38: 488-496.

 

33. Sung DH, Lee KW,  Han TH, Chang DY:  The characteristics of nerve stimulators in peripheral nerve block.  J Korean Acad Rehab Med 2000; 24: 267-274.

 

34. Lee WY, Koh SO, Yeo JS,  Han TH:  The effect of propofol on cytokine release in patients undergoing colorectal cancer surgery.  Korean J Anesthesiol 2001: 40; 155-162.

35. Son MJ, Kim HS, Kim YH, Nam HW, Lee HS, Wie HW, Han TH:  Evaluation of safety and usability of low pressure carbon dioxide insufflation in endoscopic thyroidectomy.  Korean J Anesthesiol 2002; 43: 320-324.

 

36. Kim HS, Han TH, Choi MS, Son MJ, Kwok IS, Wie HW, Kim KM:  Comparison of transesophageal Doppler monitor vs. pulmonary artery catheter in the hemodynamic indicies of major burn patients undergoing an extensive escharectomy.  Korean J Anesthesiol 2002; 43: 274-280.

 

37. Kwok IS, Wie HW, Kim HS, Han TH, Kim KM, Shin HS:  Temporary cardiac arrest during a pulmonary lobectomy-A case report.  Korean J Anesthesiol 2002; 43: 245-248.

 

38. Kwak IS, Roh WH, Son MJ, Wie HW,  Han TH, Kim KM:  The effect of ascorbic acid on skeletal muscle metabolites in the knee arthroscopic surgery using tourniquet.  J Korean Soc Intravenous Anesthesia 2002; 6: 66-71.

 

39. Woo CH, Kwak IS, Wie HW, Han TH, Kim KM:  Plasma potassium concentration change during induction of anesthesia with etomidate in major burn patients.  Korean J Anesthesiol 2002; 42: 601-605.

 

40. Choi MS, Woo CH, Kwok IS, Han TH, Kim KM, Shin HS:  Evaluation of accuracy of carbon dioxide driven disposable infusor.  J Korean Soc Intravenous Anesth 2003; 7: 49-53.

 

41. Kang HK, Lee YS, Kim YM, Wie HW, Kwok IS, Han TH, Kil HY, Kim KM:  The concentration of minimum alveolar concentration and BIS50 of inhalation anesthetics for evaluation of anesthetic potency.  Korean J Anesthesiol 2003; 44: 310 � 314.

 

42. Woo CH, Moon SH, Lee JH, Han TH, Kim HS, Kim KM:  Pseudoaneurysm in the superficial femoral artery following removal of a femoral vein catheter. Case Report.  Korean J Anesthesiology 2004; 47: 135-8.

 

43. Woo CH, Moon SH, Lee JH, Han TH, Kim HS, Kim KM:  Intramuscular injection of ketamine in the treatment of postburn neuropathic pain. Case Report.  J Korean Pain Soc 2004; 17(2); 248-251.

 

44. Han TH:  The role of anesthesiologist as a member of multidisciplinary burn care team.  Korean Burn Society Journal 2004; 7(2): 144-151.

 

45. Oh KI, Kim TW, Chang HM, Kwak IS,  Han TH, Kim KM:  Western blot analysis of alterations of skeletal muscle acetylcholine receptor subtypes in the major nurns: Burn vs. nonburn sites.  Korean J Anesthesiol 2005; 48(6): 592-599.

 

46. Kwak IS, Lee JW, Woo CH, Han TH, Kim KM:  Comparison of anti-inflammatory effect of steroid and lidocaine on major burn patients with early escharectomy.  J Korean Burn Soc 2005; 8(1): 67- 74.

 

47. Han TH, Lee JH, Lee JW, Kim JH, Oh KI, Woo CH, Kwak IS, Kim KM:  Lung injury induced by major burns does not affect fentanyl clearance.  Korean J Anesthesiol 2005; 49(6): 822-828.

 
International Journal  

1. Kim MH, Hahn TH:  The effect of clonidine pretreatment on perioperative proinflammatory cytokines, cortisol, and ACTH responses in patients undergoing total abdominal hysterectomy.  Anesth Analg 2000; 90: 1441-4.

 
2. Han TH, Kim DW, Kil HY, Inagaki Y:  The effects of fentanyl on propofol requirement, emergence from anesthesia and postoperative pain relief in propofol-nitrous oxide anesthesia.  Anesth Analg 2000; 90: 1365-71.

 

3. Kim SI, Han TH, Kil HY, Lee JS, Kim SC:  Prevention of postoperative nausea and vomiting by continuous infusion of subhypnotic propofol in female patients receiving intravenous patient-controlled analgesia.  Br J Anaesthesia 2000; 81: 898-900.

 
4. Han TH:  Opioids in cancer and non-cancer pain management in Korea: the past, present and future.  Europ J Pain 2001; 5: 73-8.
 
5. Han TH, Brimacombe J, Lee EJ, Yang HS.  The laryngeal mask airway is effective and probably safe in selected healthy parturients for elective Caesarean section.  Can J Anaesth 2001; 48: 1117-21.
 
6. Cha YD, Lee SK, Kim TJ, Han TH.  The neck crease as a landmark of Chassaignac's tubercle in stellate ganglion block: Anatomical and radiological evaluation.  Acta Anaesth Scand 2002; 46: 100-2.
 
7. Han TH, Kim HS, Bae JY, Kim K-M, Martyn JAJ:  Neuromuscular pharmacodynamics of rocuronium in patients with major burns.  Anesth Analg 2004; 99: 386-92.
 
8. Kim KM, Chang HM, Kwak IS,  Han TH:  Comparison of cardiac outputs in major burn patients undergoing extensive early escharectomy: esophageal Doppler monitor vs. thermodilution pulmonary artery catheter.  J Trauma, Injury, Infection, and Critical Care 2004; 57: 1013-7.

 

9. Han TH, Lee SY, Kwon JE, Kwak IS, Kim KM:  The effects of extensive early escharectomy on endotoxin, cytokines, and adhesion molecules kinetics in major burns.  Mediators Inflamm 2004; 13: 241-6.

 

10. Han TH, Lee JH, Kwak IS, Kil HY, Han KW, Kim KM:  The relationship between bispectral index and targeted propofol concentration is biphasic in patients with major burns.  Acta Anaesthesiol Scand. 2005; 49(1): 85-91.

 

11. Han TH, Kim JH, Yang MS, Han KW, Han SH, Jang JA, Lee JW, Jang YC, Burd A, Oh SJ:  A retrospective analysis of 19,157 burns patients: 18-year experience from Hallym Burn Center in Seoul, Korea.  Burns 2005; 31(4): 465-70.

 

12. Han TH, Han KW, Kim JW, Lee GS, Choi JH, Lee JW, Jan Y, Oh S:  Pediatric hand injury induced by treadmill.  Burns 2005; 31(7): 906-909.

 

13. Han TH:  Esophageal Doppler monitor is useful for fluid management during the perioperative and intensive care periods.  Letter to the Editor.  J Trauma, Injury, Infection and Critical Care 2005; 59(2): 508.

 
14. Han T, Harmatz JS, Greenblatt DJ, Martyn JA. Fentanyl clearance and volume of distribution are increased in patients with major burns. J Clin Pharmacol. 2007Jun;47(6):674-80.
 
15. Kaneda K, Han TH: Surgical Removal of Knotted Intravascular Pulmonary Arterial Catheter.  Clinical Journal of Trauma 2008; 1: 1-2
Publications
  1. Han TH, Greenblatt DJ, Martyn JA: Propofol clearance and volume of distribution are increased in patients with major burns. J Clin Pharmacol 2009 Jun 26


  2. Kaneda K, Han TH: Comparative population pharmacokinetics of fentanyl using non-linear mixed effect modeling: burns vs. non-burns. Burns 2009 Jun 9


  3. Karuparthy V, Kaneda K, Bellinger A, Han TH: Chewing gum: a potential cause of airway obstruction. J Anesth 2009; 23(1):168-9


  4. Han TH, Martyn JA: Onset and effectiveness of rocuronium for rapid onset of paralysis in patients with major burns: priming or large bolus. Br J Anaesth 2008 Nov 26


  5. Jang YC, Lee JW, Han KW, Han TH: Burns in epilepsy: seven years of experience from the Hallym Burn Center in Korea. J Burn Care Res 2006 Nov-Dec; 27(6):877-81


  6. Park KS, Hur EJ, Han KW, Kil HY, Han TH: Bispectral index does not correlate with observer assessment of alertness and sedation scores during 0.5% bupivacaine epidural anesthesia with nitrous oxide sedation. Anesth Analg 2006 Aug; 103(2):


  7. Jang YC, Kim YJ, Lee JW, Oh SJ, Han KW, Lee JW, Han TH: Face burns caused by flambe drinks. J Burn Care Res 2006 Jan-Feb; 27(1):


  8. Choi JS, Choi BH, Ahn HS, Kim MJ, Han TH, Rhie DJ, Yoon SH, Jo YH, Kim MS, Hahn SJ: Fluoxetine inhibits A-type potassium currents in primary cultured rat hippocampal neurons. Brain Res 2004 Aug 27; 1018(2):
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