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Timothy J. Brennan, M.D., Ph.D.
Professor


Contact Information
Job Description: Vice Chair, Research; Dr. Samir D. Gergis Professor
Office Address: 6418 JCP
Phone Number: (319) 356-7319

Email Me

Education
Graduate School
  • Pharmacology - University of Texas - San Antonio
Medical School
  • University of Oklahoma Health Sciences Center
Residency
  • University of Virginia Health Sciences Center
Fellowship
  • Neurophysiology - University of Oklahoma Health Science Center
Research Interests
  • Neural mechanisms for post-operative pain
Appointments
  • The University of Iowa College of Medicine 1993-present
Publications
  1. Spofford CM, Ashmawi H, Subieta A, Buevich F, Moses A, Baker M, Brennan TJ: Ketoprofen Produces Modality-Specific Inhibition of Pain Behaviors in Rats After Plantar Incision. Anesth Analg 2009 Nov 20


  2. Shontz R, Karuparthy V, Temple R, Brennan TJ: Prevalence and risk factors predisposing to coagulopathy in patients receiving epidural analgesia for hepatic surgery. Reg Anesth Pain Med 2009 Jul 4


  3. Udeh C, Brennan TJ: Perioperative Medicine in the United States. Perioperative Medizin. Epub 2009 Jun 18.


  4. Kang S, Brennan TJ: Chemosensitivity and mechanosensitivity of nociceptors from incised rat hindpaw skin. Anesthesiology 2009 Jun 11


  5. Wu C, Erickson MA, Xu J, Wild KD, Brennan TJ: Expression profile of nerve growth factor after muscle incision in the rat. Anesthesiology 2008 Dec 24


  6. Eisenach JC, Borgeat A, Bosnjak ZJ, Brennan TJ, Kersten JR, Kochs E, Lerman J, Warner DS, Wiener-Kronish JP: 2008 in Review: Advancing Medicine in Anesthesiology. Anesthesiology 2008 Dec; 109(6):962-72


  7. Banik RK, Brennan TJ: Trpv1 mediates spontaneous firing and heat sensitization of cutaneous primary afferents after plantar incision. Pain 2008 Nov 18


  8. Banik RK, Brennan TJ: Sensitization of primary afferents to mechanical and heat stimuli after incision in a novel in vitro mouse glabrous skin-nerve preparation. Pain 2008 Aug 31


  9. Wu C, Gavva NR, Brennan TJ: Effect of AMG0347, a transient receptor potential type V1 receptor antagonist, and morphine on pain behavior after plantar incision. Anesthesiology 2008 May 24


  10. Eisenach JC, Borgeat A, Bosnjak ZJ, Brennan TJ, Kersten JR, Kochs EF, Wiener-Kronish JP: 2007 in Review: A Dozen Steps Forward in Anesthesiology. Anesthesiology 2008 Jan; 108(1):149-155


  11. Jin HC, Keller AJ, Jung JK, Subieta A, Brennan TJ: Epidural tezampanel, an AMPA/kainate receptor antagonist, produces postoperative analgesia in rats. Anesth Analg 2007 Sep 28


  12. Eisenach JC, Brennan TJ: Anesthesiology and the press. Anesthesiology 2007 Jul; 107(1):8


  13. Wu C, Boustany L, Liang H, Brennan TJ: Nerve growth factor expression after plantar incision in the rat. Anesthesiology 2007 Jun 23


  14. Pogatzki-Zahn EM, Zahn PK, Brennan TJ: Postoperative pain--clinical implications of basic research. Best Pract Res Clin Anaesthesiol 2007 Mar; 21(1):3-13


  15. Banik RK, Woo YC, Park SS, Brennan TJ: Strain and sex influence on pain sensitivity after plantar incision in the mouse. Anesthesiology 2006 Nov 24


  16. Lee HJ, Pogatzki-Zahn EM, Brennan TJ: The effect of the AMPA/kainate receptor antagonist LY293558 in a rat model of postoperative pain. J Pain 2006 Oct 5


  17. Kim TJ, Freml L, Park SS, Brennan TJ: Lactate concentrations in incisions indicate ischemic-like conditions may contribute to postoperative pain. J Pain 2006 Sep 5


  18. Whyte DG, Brennan TJ, Johnson AK: Thermoregulatory behavior is disrupted in rats with lesions of the anteroventral third ventricular area (AV3V). Physiol Behav 2006 Mar 30; 87(3):493-9


  19. Brennan TJ, Kehlet H: Preventive analgesia to reduce wound hyperalgesia and persistent postsurgical pain: not an easy path. Anesthesiology 2005 Oct; 103(4):681-3


  20. Banik RK, Subieta AR, Wu C, Brennan TJ: Increased nerve growth factor after rat plantar incision contributes to guarding behavior and heat hyperalgesia. Pain 2005 Aug 3


  21. Brennan TJ: Incisional sensitivity and pain measurements: dissecting mechanisms for postoperative pain. Anesthesiology 2005 Jul; 103(1):3-4


  22. Zahn PK, Pogatzki-Zahn EM, Brennan TJ: Spinal administration of MK-801 and NBQX demonstrates NMDA-independent dorsal horn sensitization in incisional pain. Pain 2005 Apr; 114(3):499-510


  23. Brennan TJ, Zahn PK, Pogatzki-Zahn EM: Mechanisms of incisional pain. Anesthesiol Clin North America 2005 Mar 15


  24. Richebe P, Rathmell JP, Brennan TJ: Immediate early genes after pulsed radiofrequency treatment: neurobiology in need of clinical trials. Anesthesiology 2005 Jan; 102(1):1-3


  25. Page AJ, Brierley SM, Martin CM, Martinez-Salgado C, Wemmie JA, Brennan TJ, Symonds E, Omari T, Lewin GR, Welsh MJ, Blackshaw LA: The ion channel ASIC1 contributes to visceral but not cutaneous mechanoreceptor function. Gastroenterology 2004 Dec; 127(6):1739-47


  26. Banik RK, Brennan TJ: Spontaneous discharge and increased heat sensitivity of rat C-fiber nociceptors are present in vitro after plantar incision. Pain 2004 Oct 21


  27. Leonard PA, Arunkumar R, Brennan TJ: Bradykinin antagonists have no analgesic effect on incisional pain. Anesth Analg 2004 Sep 24


  28. Woo YC, Park SS, Subieta AR, Brennan TJ: Changes in tissue pH and temperature after incision indicate acidosis may contribute to postoperative pain. Anesthesiology 2004 Jul 28


  29. Zahn PK, Subieta A, Park SS, Brennan TJ: Effect of blockade of nerve growth factor and tumor necrosis factor on pain behaviors after plantar incision. J Pain 2004 Apr 24


  30. Brennan TJ, Zahn PK: Effect of intrathecal ACEA-1021 in a rat model for postoperative pain. J Pain 2003 Nov 19


  31. Pogatzki EM, Niemeier JS, Sorkin LS, Brennan TJ: Spinal glutamate receptor antagonists differentiate primary and secondary mechanical hyperalgesia caused by incision. Pain 2003 Sep 23


  32. Berde CB, Brennan TJ, Raja SN: Opioids: more to learn, improvements to be made. Anesthesiology 2003 Jun; 98(6):1309-12


  33. Jarvis MF, Burgard EC, McGaraughty S, Honore P, Lynch K, Brennan TJ, Subieta A, Van Biesen T, Cartmell J, Bianchi B, Niforatos W, Kage K, Yu H, Mikusa J, Wismer CT, Zhu CZ, Chu K, Lee CH, Stewart AO, Polakowski J, Cox BF, Kowaluk E, Williams M, Sullivan J, Faltynek C: A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat. Proc Natl Acad Sci U S A 2002 Dec 24; 99(26):17179-84


  34. Zahn PK, Sluka KA, Brennan TJ: Excitatory amino acid release in the spinal cord caused by plantar incision in the rat. Pain 2002 Nov; 100(1-2):65-76


  35. Brennan TJ: Frontiers in translational research: the etiology of incisional and postoperative pain. Anesthesiology 2002 Sep; 97(3):535-7


  36. Zahn PK, Pogatzki EM, Brennan TJ: Mechanisms for pain caused by incisions. Reg Anesth Pain Med 2002 Sep-Oct; 27(5):514-6


  37. Pogatzki EM, Niemeier JS, Brennan TJ: Persistent secondary hyperalgesia after gastrocnemius incision in the rat. Eur J Pain 2002 Aug 6


  38. Von Bergen NH, Subieta A, Brennan TJ: Effect of intrathecal non-NMDA EAA receptor antagonist LY293558 in rats: a new class of drugs for spinal anesthesia. Anesthesiology 2002 Jul 20


  39. Pogatzki EM, Urban MO, Brennan TJ, Gebhart GF: Role of the rostral medial medulla in the development of primary and secondary hyperalgesia after incision in the rat. Anesthesiology 2002 May; 96(5):1153-60


  40. Pogatzki EM, Vandermeulen EP, Brennan TJ: Effect of plantar local anesthetic injection on dorsal horn neuron activity and pain behaviors caused by incision. Pain 2002 May; 97(1-2):151-61


  41. Pogatzki EM, Gebhart GF, Brennan TJ: Characterization of Adelta- and C-fibers innervating the plantar rat hindpaw one day after an incision. J Neurophysiol 2002 Feb 5


  42. Hamalainen MM, Gebhart GF, Brennan TJ: Acute effect of an incision on mechanosensitive afferents in the plantar rat hindpaw. J Neurophysiol 2002 Feb; 87(2):712-20


  43. Price MP, McIlwrath SL, Xie J, Cheng C, Qiao J, Tarr DE, Sluka KA, Brennan TJ, Lewin GR, Welsh MJ: The DRASIC cation channel contributes to the detection of cutaneous touch and acid stimuli in mice. Neuron 2001 Dec 20; 32(6):1071-83


  44. Brennan TJ: Postoperative Models of Nociception. ILAR J 2001 Jun 15


  45. Vandermeulen EP, Brennan TJ: Alterations in ascending dorsal horn neurons by a surgical incision in the rat foot. Anesthesiology 2000 Oct 25


  46. Price MP, Lewin GR, McIlwrath SL, Cheng C, Xie J, Heppenstall PA, Stucky CL, Mannsfeldt AG, Brennan TJ, Drummond HA, Qiao J, Benson CJ, Tarr DE, Hrstka RF, Yang B, Williamson RA, Welsh MJ: The mammalian sodium channel BNC1 is required for normal touch sensation. Nature 2000 Oct 26; 407(6807):1007-11


  47. Pogatzki EM, Zahn PK, Brennan TJ: Effect of pretreatment with intrathecal excitatory amino acid receptor antagonists on the development of pain behavior caused by plantar incision. Anesthesiology 2000 Jul 26


  48. Pogatzki EM, Zahn PK, Brennan TJ: Lumbar catheterization of the subarachnoid space with a 32-gauge polyurethane catheter in the rat. Eur J Pain 2000 Jun 2


  49. Zahn PK, Brennan TJ: Incision-induced changes in receptive field properties of rat dorsal horn neurons. Anesthesiology 1999 Sep 15


  50. Zahn PK, Brennan TJ: Primary and secondary hyperalgesia in a rat model for human postoperative pain. Anesthesiology 1999 Mar 17


  51. Zahn PK, Brennan TJ: Intrathecal metabotropic glutamate receptor antagonists do not decrease mechanical hyperalgesia in a rat model of postoperative pain. Anesth Analg 1998 Dec 8


  52. Zahn PK, Umali E, Brennan TJ: Intrathecal non-NMDA excitatory amino acid receptor antagonists inhibit pain behaviors in a rat model of postoperative pain. Pain 1998 Mar 31


  53. Zahn PK, Brennan TJ: Lack of effect of intrathecally administered N-methyl-D-aspartate receptor antagonists in a rat model for postoperative pain. Anesthesiology 1998 Feb 3


  54. Brennan TJ, Umali EF, Zahn PK: Comparison of pre- versus post-incision administration of intrathecal bupivacaine and intrathecal morphine in a rat model of postoperative pain. Anesthesiology 1998 Jan 7


  55. Wedel DJ, White PF, Brennan TJ, Sandler A: Workshop on how to perform clinical outcome studies. University of Munster, Munster, Germany, May 22-23, 1997. Anesthesiology 1997 Oct; 87(4):1021-2


  56. Zahn PK, Gysbers D, Brennan TJ: Effect of systemic and intrathecal morphine in a rat model of postoperative pain. Anesthesiology 1997 May 1


  57. Brennan TJ, Vandermeulen EP, Gebhart GF: Characterization of a rat model of incisional pain. Pain 1996 Mar 1
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