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 | Max T. Baker, Ph.D.
Associate Professor
| Contact Information | Division: Anesthesia Research
Office Address: 3190 ML
Phone Number: (319) 335-6585
Email Me
| Education | | Graduate Education | - University of Georgia
| Postdoctoral Fellowship | - Mayo Graduate School of Medicine
| Research Interests | - Inhibitory effects of propofol on cytochrome P450 activities in rat hepatic microsomes
- Acute stimulation of trifluoroethene defluorination and cytochrome P450 inactivation in the rat by exposure to isoflurane
- Contrasting effects of 1,1,1-trichloroethane on [14C]vinyl chloride metabolism and activation in hepatic microsomes from phenobarbital- and isoniazid-treated rats
- Toxic effects of anesthetics
- Flourinated ethene metabolism and hepatoxicity
- NADPH and oxygen consumption in isoflurane-facilitated 2-chloro-1, 1-difluoroethene metabolism in rabbit liver microsomes
- Interaction of fluoroethane chlorofluorocarbon (CFC) substitutes with microsomal cytochrome P450. Stimulation of P450 activity and chlorodifluoroethene metabolism
| Appointments | - The University of Iowa College of Medicine 1989-present
| Publications | - Baker MT: Sevoflurane-lewis Acid stability. Anesth Analg 2009 Jun; 108(6):1725-6
- Baker MT: Sevoflurane: are there differences in products? Anesth Analg 2007 May 22
- Baker MT, Naguib M: Propofol: the challenges of formulation. Anesthesiology 2005 Sep 30
- Baker MT, Gregerson MS, Naguib M: Role of lipid in sulfite-dependent propofol dimerization. Anesthesiology 2004 Apr 29
- Naguib M, Baker MT, Spadoni G, Gregerson M: The hypnotic and analgesic effects of 2-bromomelatonin. Anesth Analg 2003 Aug 23
- Naguib M, Schmid PG, Baker MT: The electroencephalographic effects of IV anesthetic doses of melatonin: comparative studies with thiopental and propofol. Anesth Analg 2003 Jun 24
- Naguib M, Hammond DL, Schmid PG, Baker MT, Cutkomp J, Queral L, Smith T: Pharmacological effects of intravenous melatonin: comparative studies with thiopental and propofol. Br J Anaesth 2003 Mar 20
- Baker MT, Gregerson MS, Martin SM, Buettner GR: Free radical and drug oxidation products in an intensive care unit sedative: propofol with sulfite. Crit Care Med 2003 Mar 11
- Baker MT, Dehring DJ, Gregerson MS: Sulfite supported lipid peroxidation in propofol emulsions. Anesthesiology 2002 Nov 2
- Kim YJ, McFarlane C, Warner DS, Baker MT, Choi WW, Dexter F: The effects of plasma and brain magnesium concentrations on lidocaine-induced seizures in the rat. Anesth Analg 1996 Dec 1
- Ronnenberg WC, Wang Y, Baker MT: Isoflurane and cytochrome b5 stimulation of 2-chloro-1,1-difluoroethene metabolism by reconstituted rat CYP2B1 and CYP2C6. Biochem Pharmacol 1995 Aug 8
- Baker MT, Olson MJ, Wang Y, Ronnenberg WC, Johnson JT, Brady AN: Isoflurane-chlorodifluoroethene interaction in human liver microsomes. Role of cytochrome P4502B6 in potentiation of haloethene metabolism. Drug Metab Dispos 1995 Jan 1
- Ruzicka JA, Hidalgo JC, Tinker JH, Baker MT: Inhibition of volatile sevoflurane degradation product formation in an anesthesia circuit by a reduction in soda lime temperature. Anesthesiology 1994 Jul 1
- Baker MT, Ronnenberg WC, Ruzicka JA, Chiang CK, Tinker JH: Inhibitory effects of deuterium substitution on the metabolism of sevoflurane by the rat. Drug Metab Dispos 1993 Nov 1
- Wang Y, Olson MJ, Baker MT: Interaction of fluoroethane chlorofluorocarbon (CFC) substitutes with microsomal cytochrome P450. Stimulation of P450 activity and chlorodifluoroethene metabolism. Biochem Pharmacol 1993 Jul 6
- Baker MT, Chadam MV, Ronnenberg WC: Inhibitory effects of propofol on cytochrome P450 activities in rat hepatic microsomes. Anesth Analg 1993 Apr 1
- Baker MT, Ronnenberg WC: Contrasting effects of 1,1,1-trichloroethane on [14C]vinyl chloride metabolism and activation in hepatic microsomes from phenobarbital- and isoniazid-treated rats. Toxicol Appl Pharmacol 1993 Mar 1
- Wang Y, Baker MT: NADPH and oxygen consumption in isoflurane-facilitated 2-chloro-1,1- difluoroethene metabolism in rabbit liver microsomes. Drug Metab Dispos 1993 Mar 1
- Spiegel DA, Dexter F, Warner DS, Baker MT, Todd MM: Central nervous system toxicity of local anesthetic mixtures in the rat. Anesth Analg 1992 Dec 1
- Baker MT, Ronnenberg WC: Acute stimulation of trifluoroethene defluorination and cytochrome P450 inactivation in the rat by exposure to isoflurane. Toxicol Appl Pharmacol 1992 May 11
- Bates JN, Baker MT, Guerra R Jr, Harrison DG: Nitric oxide generation from nitroprusside by vascular tissue. Evidence that reduction of the nitroprusside anion and cyanide loss are required. Biochem Pharmacol 1991 Dec 11; 42 Suppl():S157-65
- Baker MT, Vasquez MT, Chiang CK: Evidence for the stability and cytochrome P450 specificity of the phenobarbital-induced reductive halothane-cytochrome P450 complex formed in rat hepatic microsomes. Biochem Pharmacol 1991 Jun 1
- Baker MT, Vasquez MT, Bates JN, Chiang CK: Metabolism of 2-chloro-1,1-difluoroethene to glyoxylic and glycolic acid in rat hepatic microsomes. Drug Metab Dispos 1990 Sep 1
- Baker MT, Bates JN: Metabolic activation of the halothane metabolite, [14C]2-chloro-1,1-difluoroethene, in hepatic microsomes. Drug Metab Dispos 1988 Mar 1
- Baker MT, Bates JN, Leff SV: Stimulatory effects of halothane and isoflurane on fluoride release and cytochrome P-450 loss caused by metabolism of 2-chloro-1,1-difluoroethene, a halothane metabolite. Anesth Analg 1987 Nov 1
- Baker MT, Bates JN, Leff SV: Comparative defluorination and cytochrome P-450 loss by the microsomal metabolism of fluoro- and fluorochloroethenes. Drug Metab Dispos 1987 Jul 1
- Baker MT, Bates JN, Van Dyke RA: Stabilization of the reduced halocarbon-cytochrome P-450 complex of halothane by N-alkanes. Biochem Pharmacol 1987 Apr 1; 36(7):1029-34
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